Figure 4 - full size


Figure 4.
Fig. 4. Comparison of the binding of EPA and AA within the cyclooxygenase active site. A, stereo view of EPA (light blue) and AA (yellow) overlapped in the cyclooxygenase active site. Active site residues are colored as in Fig. 1, and modeled hydrogen atoms on C-13 of both substrates are shown. B, stereo view of the -end of EPA and AA from the perspective of Tyr-385 at the top of the cyclooxygenase active site (rotation of 90° about the horizontal axis in A).

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2001, 276, 37547-37555) copyright 2001.