Figure 3 - full size


Figure 3.
Fig. 3. Structural organization of the VL-facing side of a VH and its corresponding side in VHHs and a partial camelized human VH. A, VL eye-view of a human VH (1igm, Ref. 50). B, the partial camelized human VH (1vhp, Ref. 36). C, the corresponding side of a VHH, cAb-Lys3 (1mel, Ref. 6) and D, cAb-CA05 (this study). The side chain of residues that take a different conformation among VH and VHH are shown in ball-and-stick and are denoted by their single letter code. The side chains of Arg-38, Tyr-90, and Tyr-91 having similar orientations in VH and VHHs are shown for reference.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2001, 276, 26285-26290) copyright 2001.