Figure 3 - full size

 

Figure 3.
Fig. 3. Interactions between DHLA and cyclooxygenase active site residues. A schematic diagram of the interactions between DHLA and residues within the cyclooxygenase channel. Every other carbon atom of DHLA is labeled, and the hydrogens for C-13 have been modeled. All dashed lines represent interactions within 4.0 Å between the specific side chain atom of the protein and DHLA. Only 3 of the 62 contacts between DHLA and cyclooxygenase channel residues are hydrophilic.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2001, 276, 10358-10365) copyright 2001.