Fig. 3. Interactions between DHLA and cyclooxygenase
active site residues. A schematic diagram of the interactions
between DHLA and residues within the cyclooxygenase channel.
Every other carbon atom of DHLA is labeled, and the hydrogens
for C-13 have been modeled. All dashed lines represent
interactions within 4.0 Å between the specific side chain
atom of the protein and DHLA. Only 3 of the 62 contacts between
DHLA and cyclooxygenase channel residues are hydrophilic.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem