Figure 6 - full size


Figure 6.
Figure 6. Superposition of mutant TK[HSV1](Q125N) in complex with dT (thick solid lines, C atoms marked by small dots, hydrogen bonds are dotted) with wild-type TK[HSV1] in complex with aciclovir (thin solid lines),[19] ganciclovir (thin dotted lines)[19]and dT (thick dotted lines).[19] For sake of clarity, side chains are only drawn for TK[HSV1](Q125N):dT and TK[HSV1]:aciclovir. Water molecules and hydrogen bonds are depicted for TK[HSV1](Q125N):dT (black circles) and TK[HSV1]:aciclovir (pale circles). For aciclovir, only the location of the hydroxyl group at the 5 -OH position of dT is shown.

The above figure is reprinted by permission from John Wiley & Sons, Inc.: Proteins (2000, 41, 545-553) copyright 2000.