Figure 3 - full size

 

Figure 3.
Fig. 3. A schematic of interactions between AA and COX channel residues (30). Carbon atoms of AA are yellow, oxygen atoms red, and the 13proS hydrogen blue. All dashed lines represent interactions within 4.0 Å between the specific side chain atom of the protein and AA; the structures AA-1 and AA-2 revealed the same set of 49 contacts. Only two of these contacts between AA and the COX channel residues are hydrophilic. The carboxylate forms a salt bridge to the guanidinium atom of Arg120 (distance = 2.4 Å; angle = 143°) and a hydrogen bond to the OH group of Tyr355 (distance = 3.1 Å; angle = 115°). (Inset) A schematic of the chemical structure of AA.

The above figure is reprinted by permission from the AAAs: Science (2000, 289, 1933-1937) copyright 2000.