Figure 2: COX-2 dimer interface solvent channel. The two
monomers (coloured green and blue) of the COX-2 dimer are shown
from the membrane face (a) or side (b). Cyclooxygenase and
peroxidase active sites are marked by AA (red) and haem
molecules (orange, superimposed onto the H207A-AA structure),
respectively. Solvent molecules are shown as yellow spheres.
The above figure is reprinted
by permission from Macmillan Publishers Ltd: