Figure 2 - full size

 

Figure 2.
Figure 2: COX-2 dimer interface solvent channel. The two monomers (coloured green and blue) of the COX-2 dimer are shown from the membrane face (a) or side (b). Cyclooxygenase and peroxidase active sites are marked by AA (red) and haem molecules (orange, superimposed onto the H207A-AA structure), respectively. Solvent molecules are shown as yellow spheres.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nature (2000, 405, 97-0) copyright 2000.