Figure 3 - full size

 

Figure 3.
Fig. 3. Stereo diagram showing the active sites of CYP-3 and human cyclophilin A. This clearly shows the complete conservation of all 13 residues important in the binding of CsA, with the only significant structural difference between human CypA and CYP-3 being in the conformation adopted by Arg62 that places the side chain atoms 0.7Å apart.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (1999, 274, 34877-34883) copyright 1999.