Figure 3. Comparison of the pyrrolidinone ring conformation and interactions of the hydroxymethyl groups with
the NA active site. (a) BANA205, (b) BANA206. In (a), the pyrrolidinone ring is nearly flat, while in (b) the ring is
puckered. The puckering difference allows the hydroxymethyl groups to interact differently with NA residues. Active
site residues are indicated.
The above figure is reprinted
by permission from Elsevier:
J Mol Biol