Figure 3 - full size

 

Figure 3.
Figure 3. Comparison of the pyrrolidinone ring conformation and interactions of the hydroxymethyl groups with the NA active site. (a) BANA205, (b) BANA206. In (a), the pyrrolidinone ring is nearly flat, while in (b) the ring is puckered. The puckering difference allows the hydroxymethyl groups to interact differently with NA residues. Active site residues are indicated.

The above figure is reprinted by permission from Elsevier: J Mol Biol (1999, 293, 1107-1119) copyright 1999.