Figure 4 - full size


Figure 4.
Figure 4. Cartoon representation of ligand binding to four α/β-barrel PEP/pyruvate-utilizing enzymes. The β/α motifs are numbered sequentially. For PEP mutase, helix 8 is colored yellow because it is contributed by a neighboring molecule. The loop connecting the β/α motif 3 in pyruvate kinase corresponds to a whole domain and is shown as a broken yellow line. Motifs 1 and 2 in enolase do not obey the classical topology of β/α motifs. Residues that interact with PEP/pyruvate/oxalate are colored red. Residues that interact with Mg^2+ are colored blue.

The above figure is reprinted by permission from Cell Press: Structure (1999, 7, 539-548) copyright 1999.