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Figure 9.
FIGURE 9. Structure-based catalytic mechanism of
tyrosinase. The oxy form of tyrosinase catalyzes the conversion
of monophenol to the corresponding quinone through the
ortho-diphenol formation. In this scheme, His^54 is released
from the Cu^A site, resulting in the formation of the bidentate
intermediate. The met and oxy forms of tyrosinase can catalyze
the conversion of ortho-diphenol to the corresponding quinone.
This reaction should progress similarly to that of catechol
oxidase.
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