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Figure 8.
Fig. 8. Disruption of the β2/β3 region interface in the
Vav1/Rac1 structure. Comparison of the Tiam1/Rac β2/β3 region
(left) and the Vav/Rac β2/β3 region (right). Tiam1 (cyan)
forms an integrated network with the B2/B3 region of Rac1 (grey)
in addition to a hydrogen bond between Trp56 of Rac1 and His1178
of Tiam1. Vav1 (blue) forms only one hydrogen bond in this
region, between Ser41 of the B2/B3 of Rac1 (green) and Arg319 of
the DH domain of Vav1. In addition, Trp56 of Rac1 does not form
any interaction with the DH domain of Vav1, polar or hydrophobic.
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