Figure 8.
FIGURE 8. Superimposed stereographic view of the AG9^145
and AG9^134 PI binding pockets in complex with Ins(1,4,5)P[3]
and Ins(1,3,4)P[3], respectively. The PH domain of AG9^145 is
colored cyan with bound Ins(1,4,5)P[3] in purple; the AG9^134 PH
domain is colored green with bound Ins(1,3,4)P[3] in pink.
Orientation of bound PI(4,5)P[2] and PI(3,4)P[2] are related by
a rotation of 180° about the P1-P4
axis of the inositol ring.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2007,
282,
13864-13874)
copyright 2007.
180° about the P1-P4
axis of the inositol ring.