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Figure 10.
Figure 10. Cartoon representation of the two zinc fingers
from (a) MBP-1^41 (mf1-2), and (b) GLI^33 (gf1-2). (a) The more
extended arrangement of mf1-2 (structure 1 from PDB entry 1BBO),
in which side-chain interactions forming the finger 1–2
interface involving residues from finger 1 (red), finger 2
(green), and the linker (gray) are indicated and annotated. In
(b), amino acid side-chains from finger 1 (red), finger 2
(green), and the linker (gray) that appear to stabilize the
gf1-2 two-finger structure (PDB entry 2GLI) are shown. Although
portrayed here as an isolated two-finger domain for clarity, the
X-ray structure from which the gf1-2 cartoon structure was
derived consisted of Co(II)-bound GLI fingers 1–5 in complex
with DNA (metal ligands are not included in the PDB entry). In
the GLI-DNA structure, only fingers 2–5 made contact with the
DNA.
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