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Figure 8.
Figure 8 Stereo images of Gads-SH2 and Grb2-SH2 structures. (A)
View of the +1 binding site in the Gads-SH2/pLAT226 complex.
Relevant stretches of the Gads-SH2 polypeptide backbone are
cream; labels identify side chains and bound waters (red balls)
in the vicinity of +1 Glu of pLAT226 (silver). The side chain of
the modeled +1 His residue is green. (B) The +1 binding site in
the Grb2-SH2/KPFpYVNV complex (PDB entry code 1tze) (Rahuel et
al, 1996). The Grb2-SH2 polypeptide backbone is cream. Side
chains and waters (red balls) in the vicinity of +1 Glu of the
bound peptide (silver) are labeled; the modeled +1 His is green.
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