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Figure 8.
Figure 8. Schematic Diagram of Potential Rearrangement in
the Clamp Loader Complex upon Nucleotide BindingThis represents
a hypothetical sequence of events based on structural and
biochemical evidence of conformational changes presented here
and in [9]. Only three subunits of the g complex are shown for
clarity. Green: d'; red: g1; blue: g2. S1: sensor 1/switch 2
helix a7, containing the SRC motif; P: P loop; S2: sensor 2
helix a10. Close contacts between the subunits are marked by
yellow circles. ATP is drawn bound to the g1 subunit (brown
circles are for the base and sugar, and white are for the
phosphate groups). Arginine from the conserved SRC motif is
indicated on the S1 (sensor 1) helices.
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