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Figure 7.
Figure 7. Stereo views of the cata-
lytic site of E. coli GST superposed
on the structures of eukaryotic
theta and alpha GSTs. The ligand
molecules, glutathione sulfonate in
E. coli GST, S-hexyl-glutathione
in theta GST from A. thaliana
(Reinemer et al., 1996), and S-ben-
zyl-glutathione in human GST
alpha 1-1 (Sinning et al., 1993), and
the C
a
atoms of the enzymes are
superposed in the Figure. The
structure for the liganded E. coli
GST is colored red, and those for
the theta (a) and alpha (b) GSTs
are in green and blue, respectively.
Residues from the accompanying
subunit are shown by asterisks.
The ligand molecules are in light
colors. Hydrogen bonds formed in
the catalytic site of E. coli and
alpha are drawn as dotted lines.
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