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Figure 7.
Figure 7. Superimposition of the crystal structures of
Nef–SH3 complexes. Stereoview of the interface showing the
environment of the Nef polyproline type II helix region
(residues 71–77) and conserved residues. The two Nef isolates
are superimposed: Nef HIV-1[LAI] isolate in green and Nef[T71R]
HIV-1[NL43] isolate (Nef-D molecule in PDB entry 1EFN in red.
The hydrogen bond between the Arg71 sidechain and Tyr137 of
Fyn[R96I] is shown as a dotted white line. The SH3 domains are
coloured in light purple and dark purple for Fyn[wt] and
Fyn[R96I] (SH3-C molecule in PDB entry 1EFN), respectively.
(Figure generated using the program O [69].)
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