Figure 7.
Figure 7. A Model of Ectodermal Dysplasia Mutations in NEMO
Mutations in NEMO UBAN domain found in ectodermal dysplasia
(D304, E308, and R312) (red) are all involved in binding to
linear diubiquitin at amino acids R72, L73, and R74 in distal
ubiquitin molecule (orange) or Q2, F4, and E64 in proximal
ubiquitin molecule (gold).
The above figure is reprinted
by permission from Cell Press:
Cell
(2009,
136,
1098-1109)
copyright 2009.
