|
Figure 7.
Ribbon representation of the PID/PTB domains in complex with
target peptides. PID2 of Fe65L1 is shown in green, and other
PID/PTB domains are shown in light green. The target peptides
are shown in magenta. In the target peptide, the NPX(p)Y motif,
if it exists, is shown in cyan where the tyrosine or
phosphorylated tyrosine residue is indicated, and the region
forming the antiparallel β-sheet with the β5 strand of the
PID/PTB domain is shown in red. A, Fe65L1 PID2 and APP peptide.
B, X11 PTB domain and APP peptide. C, IRS-1 PTB domain and IL-4
peptide. D, Numb PTB domain and GPpY-containing peptide. E,
SNT-1 PTB domain and fibroblast growth factor receptor 1 (FGFR1)
peptide. The unique C-terminal β-strand of SNT-1 is shown in
blue. F, Talin F3 domain and integrin peptide. The Protein Data
Bank accession code for each complex is shown under each ribbon
representation in parentheses.
|
