|
Figure 7.
Figure 7. Model of Neurexin Phosphorylation by CASK
Neurexin (Nx) and neuroligin (NL) are thought to interact
extracellularly with each other across the synaptic cleft and to
associate intracellularly with the MAGUKs CASK and PSD-95,
respectively. CASK is recruited to the cytosolic C-tail of
neurexin via the CASK PDZ domain and phosphorylates the neurexin
C-terminal tail. Protein 4.1, which binds the C-tail of neurexin
as well as CASK, nucleates actin filaments, modulating the
presynaptic cytoskeleton. The red indicator depicts the
inhibition of CASK CaM-kinase activity due to an increase in
cytosolic divalent cations.
|
