|
Figure 7.
Figure 7 Comparison of Plk-1-3H10 with further
kinase-ankyrin-repeat (AR) protein complexes. (a)-(c) Tube
diagrams showing the overall folds of kinases in complex with AR
proteins: (a) Plk-1-DARPin 3H10; (b) Cdk6-P19INK4D inhibitor
complex (Russo et al., 1998[Russo, A. A., Tong, L., Lee, J. O.,
Jeffrey, P. D. & Pavletich, N. P. (1998). Nature (London), 395,
237-243.]; chains A and B from PDB entry 1bi8 ); (c) APH-AR
inhibitor complex (Kohl et al., 2005[Kohl, A., Amstutz, P.,
Parizek, P., Binz, H. K., Briand, C., Capitani, G., Forrer, P.,
Plückthun, A. & Grütter, M. G. (2005). Structure, 13,
1131-1141.]; chains A and B from PDB entry 2bkk ). In all panels
the kinase is coloured gold and the AR protein is coloured cyan.
The ADP in APH is shown in ball-and-stick representation (C, N,
O and P atoms are coloured grey, blue, red and green,
respectively) and is a reference for the ATP site. This figure
was prepared with DINO (Philippsen, 2002[Philippsen, A. (2002).
DINO. http://www.dino3d.org .]).
|
