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Figure 7.
Figure 7. Model for Autoregulation of Grp1 Family GEFs
After PtdIns(3,4,5)P[3]-dependent plasma membrane recruitment of
Grp1 family GEFs, lateral association with Arf6-GTP
simultaneously enhances membrane partitioning and shifts the
equilibrium toward the catalytically competent conformation.
Other mechanisms, including phosphorylation of PKC sites in the
polybasic motif of Cytohesin-1, may be required for full
activation.
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