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Figure 7.
Figure 7. Ligand-Binding Surfaces in the IgV Domain of TIM-1
Receptors
Surface representation of the mTIM-1 domain
structure. Surface involved in the homophilic interaction is
pink. Residues in a conformational epitope built by the tip of
the long CC′ loop and the FG loop onto the GFC β sheet are
colored red and orange, respectively. The surface where an
mkTIM-1 polymorphism (Lys88Gln) has been mapped is in blue. The
mutation identified the side of the domain recognized by a mAb
blocking HAV binding to its mkTIM-1 receptor (Feigelstock et
al., 1998a). Surface corresponding to the Asn residue to which
glycans will be linked in the primate TIM-1 receptors is green.
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