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Figure 7.
Figure 7. Comparison of Imatinib-Bound Structures
(A)
Structure of c-Src•imatinib (this work, PDB code 2OIQ). The
activation loop is disordered from residue 408 to residue 420,
and the phosphate-binding P loop is extended, leaving the
phenylalanine side chain solvent exposed.
(B) Structure of
Abl•imatinib (PDB code 1OPJ [Nagar et al., 2002]). The
phosphate-binding loop is kinked toward the C lobe of the
kinase, allowing for hydrogen bonds between Tyr253 and Asn322
(not shown).
(C) Structure of c-Kit•imatinib (PDB code
1T46 [Mol et al., 2004]). The phosphate-binding loop is
extended, as seen in the structure of c-Src, and Phe600 is
solvent exposed.
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