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Figure 7.
FIGURE 7. Stereographic view of AG9 PH domain binding to
Ins(1,4,5)P[3] (A), Ins(1,3,4)P[3] (B), and Ins(1,3,5)P[3] (C).
Experimental F[o] - F[c] electron density map prior to modeling
of bound ligand is shown as a wire mesh contoured at 2.5 sigma.
PI-interacting residues are shown as stick models with hydrogen
bonds indicated by dashed lines. Phosphate positions of the
inositol ring are labeled. Water molecules are indicated by red
spheres. In C only a single phosphate moiety of the Ins(1,3,5)P3
ligand is modeled.
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