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Figure 7.
Figure 7. Model for H3K4me3-Directed Activity of NuA3
(A) Set1, the H3K4 HMT, is recruited to promoter-proximal
nucleosomes at the ORF to be activated, resulting in H3K4me3.
(B) NuA3 is targeted to and/or retained at sites of H3K4me3
through interactions with the PHD finger of Yng1, promoting
H3K14ac via the Sas3 HAT, positively regulating downstream
transcription events.
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