Figure 7.
Figure 7. Common Docking Domain and ED Site of MAP Kinases
Compared to MARK2 The structures of (A) MARK2 and (B) ERK2
(PDB code 2ERK [Canagarajah et al., 1997]) are shown in the same
orientations after least-squares superposition of 35 residues
from helix E to the catalytic loop. The common docking domain
(CD, in red) according to Tanoue and Nishida (2003) is C
terminal to the kinase domain and corresponds in MARK to the
first half of the tether connecting the kinase domain to the UBA
domain (residues vert,
similar 305-315). The C-terminal extensions following the CD
domain (linker and UBA domain in MARK2) are shown in purple.
Characteristic for the CD domain is a cluster of negatively
charged residues exposed to the surface, located in a bulge at
the end of the catalytic domain (stick model representation).
The above figure is reprinted
by permission from Cell Press:
Structure
(2006,
14,
173-183)
copyright 2006.
vert,
similar 305-315). The C-terminal extensions following the CD
domain (linker and UBA domain in MARK2) are shown in purple.
Characteristic for the CD domain is a cluster of negatively
charged residues exposed to the surface, located in a bulge at
the end of the catalytic domain (stick model representation).