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Figure 7.
FIG. 7. STI-571 binding and interactions with c-Kit kinase.
A, chemical structure of STI-571 and F[obs] - F[calc] omit
difference electron density calculated prior to building the
inhibitor into the co-crystal structure, contoured at 3  (blue)
and 6 (red). Key hydrogen
bonds are depicted. B, stereo view of STI-571 (purple) binding
to c-Kit showing key hydrogen bonds formed with the hinge
residue Cys673, gatekeeper residue Thr670, and conserved residue
Glu640. The polypeptide surrounding Trp557 from the virgin
autoinhibited c-Kit structure is shown superimposed on the
STI-571 complex structure.
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