Figure 7.
Fig. 7. Recognition of Fc by multiple ligands. Structural
comparison among the complexes of (A) Fc RIIIB-Fc;
(B) FcRn-Fc (PDB entry 1FRT); (C) rheumatoid factors RF-Fc (PDB
entry 1ADQ); and (D) bacterial protein A-Fc (PDB entry 1FC2).
Protein G binds similar to Fc as does protein A. Due to its
symmetric interaction with ligand, only one chain of Fc is shown
in the FcRn·Fc, RF·Fc and protein A·Fc
complexes. The corresponding Fc regions are colored in cyan and
shown in similar orientations. The ligands to Fc are colored in
green and the [2]-microglobulin
of FcRn is shown in red. Only the variable domain of RF is
shown. The carbohydrates are shown in ball-and-stick models.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2001,
276,
16469-16477)
copyright 2001.
RIIIB-Fc;
(B) FcRn-Fc (PDB entry 1FRT); (C) rheumatoid factors RF-Fc (PDB
entry 1ADQ); and (D) bacterial protein A-Fc (PDB entry 1FC2).
Protein G binds similar to Fc as does protein A. Due to its
symmetric interaction with ligand, only one chain of Fc is shown
in the FcRn·Fc, RF·Fc and protein A·Fc
complexes. The corresponding Fc regions are colored in cyan and
shown in similar orientations. The ligands to Fc are colored in
green and the 
[2]-microglobulin
of FcRn is shown in red. Only the variable domain of RF is
shown. The carbohydrates are shown in ball-and-stick models.