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Figure 7.
Figure 7. Stereodiagrams of DNA bound to the fingers domain
of the MMLV RT fragment as modeled in the previously defined
binding cleft in HIV-1 RT. (a) A trace rendering shows the
fragment of MMLV RT in blue including the fingers and palm
domains superimposed on the fingers, palm, and thumb domains
from HIV-1 RT (2hmi structure) [Ding et al 1998]. DNA as bound
to the fingers domain in form IIb crystals is shown as a stick
model in red. The superpositioning of the fingers and palm
domains from MMLV RT and HIV-1 RT is based on the 160 most
similar residues as reported by [Georgiadis et al 1995] and
listed in the legend in Figure 2. (b) The same molecules are
superimposed as in (a). The DNA shown in red from the HIV-1
RT-DNA-Fab complex structure (2hmi) is shown for comparison in a
similar view along the cleft formed by the fingers, palm, and
thumb domains.
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