Figure 7.
Figure 7 Possible synergistic bindings at enhancer elements. (A)
A side view of the surface representation of the IFN- enhancer
with the DNA binding domains of the transcription factors; IRFs
(purple and wine red) bound to the PRD III and I sites, ATF-2
-c-Jun (blue and green) bound to the PRD IV, and NF- B,
p65 (light green) -p50 (light blue) heterodimer bound to the PRD
I sites. The DNA sequence and the binding sites are indicated at
the top. Minor grooves of the HMG I(Y) binding sites are
indicated with labels. The N and C termini are indicated to show
the locations of their activation domains that link to the N
termini of ATF-2 -Jun and the C termini of IRF and p65. (B) A
side view of the surface representation showing the IRF-2 DNA
binding domains (purple and wine red) bound to the TATA-box
region of the VCAM-1 gene, together with bound TBP (light blue)
and the TFIIB core (green). An IRF-2 DNA binding domain (purple)
bound to the upstream GAAA core sequence contacts with the
N-terminal domain of the TFIIB core.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO J
(1999,
18,
5028-5041)
copyright 1999.
enhancer
with the DNA binding domains of the transcription factors; IRFs
(purple and wine red) bound to the PRD III and I sites, ATF-2
-c-Jun (blue and green) bound to the PRD IV, and NF- 
B,
p65 (light green) -p50 (light blue) heterodimer bound to the PRD
I sites. The DNA sequence and the binding sites are indicated at
the top. Minor grooves of the HMG I(Y) binding sites are
indicated with labels. The N and C termini are indicated to show
the locations of their activation domains that link to the N
termini of ATF-2 -Jun and the C termini of IRF and p65. (B) A
side view of the surface representation showing the IRF-2 DNA
binding domains (purple and wine red) bound to the TATA-box
region of the VCAM-1 gene, together with bound TBP (light blue)
and the TFIIB core (green). An IRF-2 DNA binding domain (purple)
bound to the upstream GAAA core sequence contacts with the
N-terminal domain of the TFIIB core.