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Figure 6.
Figure 6. The Hydrophobic Groove of the M Domain Is Not
Empty in the CrystalThe flexible finger loop of one M domain
(magenta; residues 337–355 shown) inserts into the proposed
signal sequence binding groove of another M domain (white,
molecular surface representation), forming a hydrophobic cavity
in the center of the groove that may contain detergent from the
crystallization solution. This protein–protein interaction may
represent an example of the extent to which the M domain has
evolved to accommodate a wide variety of hydrophobic sequences.
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