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Figure 6.
Figure 6. Stereo view of a superposition of the structures
of SUMO-1 (black) and ubiquitin (red) using the Program O [Jones
et al 1991]. The overlay of the C^α backbone shows the
similarity between the two protein cores of SUMO-1 and
ubiquitin, although these proteins share only 18% sequence
identity. Also marked are side-chains of Gln69 of SUMO-1 and
Lys48 of ubiquitin, which is important for the formation of
polyubiquitin and which are located at the same position. The
indicated C-terminal di-glycine motif is localized in a very
flexible region, functionally conserved and located in similar
positions relative to the overall protein fold.
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