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Figure 6.
Figure 6. The 12 residues of the EF-hand site I of N-TnC. In this and Figure 7, residues are color-coded according to
type: aliphatic hydrophobic are green; aromatic residues are brown; methionine are yellow; positively charged resi-
dues are blue; negatively charged residues are red and polar side-chains, Ser, Thr, Asn and Gln are orange and pink.
Main-chain atoms C
a
, C, D, N are depicted in white. Calcium is shown as a magenta sphere. Water molecules (five is
equatorial, nine is axial) are shown as cyan spheres. Water molecules are labelled as 5 or 9 depending on which
liganding position in the EF-hand loop they occupy. Hydrogen bonds are denoted as broken yellow lines. (a) Ligand-
ing residues in the 2-Ca
2+
form; (b) hydrogen bonding patterns within the 2-Ca
2+
form; (c) a similar view of site I in
the apo 0-Ca
2+
form of N-TnC. The Figure was generated using Raster 3D (Merrit & Murphy, 1994).
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