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Figure 6.
Figure 6. The Domain Structure of Human Fibrillin-1 and a
Model for the Organization of Fibrillin Monomers within
Connective Tissue MicrofibrilsThe domain structure of human
fibrillin-1 ([41]) is shown on top, and the model for the
organization of fibrillin monomers within connective tissue
microfibrils is shown below. The position of the cbEGF domains
(32–36) shown in Figure 6 is highlighted. In the model,
fibrillin monomers are shown as arrows. The monomers are
arranged in a parallel, staggered, head-to-tail arrangement,
with N- and C-termini in the “bead” regions (shaded). The
dimensions of the fib32–33 pair, combined with the results of
antibody labeling data ( [46]), suggest that the extended
fibrillin monomer spans two interbead regions with 50% overlap,
as shown. The inverted Ys denote the position within each
monomer of a putative antibody binding site.
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