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Figure 6.
Treatment of dogs with celecoxib interferes with the effect
of low-dose aspirin on ex vivo platelet aggregation.
Purpose-bred beagle dogs (n = 6, 10–12 kg) were administered
low-dose aspirin alone (1.16 mg/kg, p.o.; LD ASA), celecoxib
alone (1.43 mg/kg, po bid; CBX), or both celecoxib plus low-dose
aspirin (CBX + LD ASA) for a period of three days. At the
conclusion of each treatment regimen, platelet-rich plasma was
prepared by centrifugation from venous whole blood collected in
3.7% sodium citrate. Ex vivo platelet aggregation responses to
three platelet agonists [AA (650 μM), adenosine diphosphate (20
μM), and γ-thrombin (70 nM)] were recorded. Data are expressed
as the mean ± SEM. *** indicates p < 0.001 when each time
point is compared to the same agonist at day 0 by two-way ANOVA.
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