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Figure 6.
Figure 6. Signal Transduction Model
In the model, the
signal reaches the catalytic core of the HK via helix α1
rotation. This rotation modifies DHp packing and the position of
the associated CA domain. The latter domain either approaches
the phosphoacceptor His, triggering the autokinase reaction
(center), or moves away to generate the appropriate docking
surfaces for either the interaction with nonphosphorylated RR,
promoting phosphotransfer (right), or the interaction with the P
 vert,
similar RR, promoting dephosphorylation (left).
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