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Figure 6.
Multiple IL-18 epitopes mediate binding to multiple
receptors. IL-18Rα and IL-18BP were modeled based on the IL-1R1
crystal structure (13) (Protein Data Bank entry 1ITB) and are
shown bound to IL-18. a, engagement of IL-18 (gray) by IL-18Rα
completely blocks the proposed ABT-325 epitope (magenta), and
β-strands B and D (red) in domain 2 collide with 125-2H CDR H2.
The IL-18BP (red) and IL-18Rβ (green; “Site 3” (see Ref.
1)) epitopes are also shown. b, close up view of the collision
between 125-2H and IL-18Rα, viewed from behind relative to a.
c, 125-2H, ABT-325, and IL-18BP can all bind IL-18
simultaneously, since their epitopes do not overlap.
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