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Figure 6.
PD-1/PD-L interaction at the cell–cell interface.
Noncovalent interactions between PD-1 and PD-Ls are sufficient
to drive their enrichment at a pseudosynapse. (A and B) PD-1 and
PD-L1 (A) or PD-L2 (B) expressed in CHO cells are recruited to
the cell–cell contact area and form conjugates that are
analogous to the immunological synapse. (Left)
PD-1-CFP-expressing cells in blue. (Center) PD-L1-YFP or
PD-L2-YFP-expressing cells in yellow. (Right) Overlay of the CFP
and YFP images. (C) Model of the PD-1/PD-L2 complex in the
immunological synapse. A number of receptor–ligand assemblies
have dimensions that are compatible with colocalization to the
central zone of the immunological synapse.
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