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Figure 6.
Figure 6. Structure of the Ca^2+ Binding Region from β-NRX1,
and Comparison with LNS2 from α-NRX1
(A) Image of 1.7
Å 2F[o]-F[c] electron density contoured at 1.0 σ in the
region of the Ca^2+ binding site.
(B) The Ca^2+ ion is
ligated by four ligands in the Ca^2+ binding site, one water
molecule, and a glutamic acid side chain from a symmetry mate.
(C) Superposition of LNS2 from α-NRX1 (blue) on the
β-NRX1 structure (green and yellow) shows that the Ca^2+
binding sites are positioned identically in each LNS domain.
Ligation by the N208 side chain appears to be common to all the
β-NRX but absent from many other LNS domains of α-NRX.
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