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Figure 6.
Fig. 6. Structure-based mutational analyses. (a) Cleavage of
Lys48-linked polyubiquitin chains by wild-type and mutant A20.
(b) Cleavage of Lys48-linked diubiquitin by wild-type and mutant
A20. (c) Deubiquitination of Lys63-linked polyubiquitinated
GST-TRAF6 by wild-type and mutant A20. The left panel shows the
appearance of ubiquitin chains in the supernatant of glutathione
beads. The right panel shows the decrease in the
polyubiquitination of GST-TRAF6 bound to glutathione beads.
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