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Figure 6.
FIGURE 6. Stereo diagram showing INH bound in the ascorbate
binding pocket of sAPX. Hydrogen bonding interactions are
observed between INH and Arg-172 and Lys-31 and via a water to
the propionate group of the heme. There are INH molecules bound
in identical positions in the sAPX (W41A) and sAPX (H42A)
structures. The first INH molecule bound in the distal cavity is
also shown to aid orientation. The protein is shown in green,
the heme group in blue, and INH in pink. Waters are represented
as red spheres. The observed F[o] - F[c] difference density
(contoured at 3  ) for the INH molecules
is shown in green. Figs. 2, 3, 4, 5, 6 were prepared with PyMOL
(22).
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