Figure 6 - full size

 

Figure 6.
FIGURE 6. Comparison of AM7 binding to c-Met with activated Lck. AM7 does not clash with the activation loop of activated Lck, but it does clash with the active conformation of the Lck C-helix. All of the protein backbone atoms from the two crystal structures were used to guide the alignment, but only the Lck protein is shown in the figure. AM7 is colored yellow, and the Lck protein is colored blue.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2008, 283, 2675-2683) copyright 2008.