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Figure 8.
Fig. 8. Structural superposition models show how the
displacement of β5 in L69S could affect its binding to UIMs of
S5a but not to UBAs of hHR23A. Shown is a superimposition of
L69S Ub structure on the known structures of WT Ub complexes:
(a) Ub:UIM-2 (PDB code 1YX6); (b) Ub:UBA-1; (c) Ub:UIM-1 (PDB
code 1YX6); and (d) Ub:UBA-2. WT Ub is shown in blue, L69S Ub is
in green, and the UIM or UBA domains are in red. The Ub:UIM
structures are from Ref. 26, while the Ub:UBA docked models are
from Ref. 28.
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