Figure 6 - full size

 

Figure 6.
Fig. 6. The crystal structure of LoopA at low pH. (A) The repeating unit contains a domain-swapped dimer (cyan, chain 1; green, chain 2) and a monomer (purple). Electron density is not present for the redesigned loop in the monomer. In the dimer, the loop opens up, and strands 1 and 2 insert into the partner molecule. (B) The designed loop appears to be stabilized by protonated glutamic acid residues.