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Figure 6.
Figure 6. The Autoinhibition by the Molecular Brake Is a
Common Regulatory Mechanism for Many RTKs
(A)–(E) show
the presence of the engaged molecular brake at the kinase hinge
region of unphosphorylated wild-type FGFR1 (PDB ID: 1FGK), CSF1R
(PDB ID: 2I1M), VEGFR2 (PDB ID: 1VR2), TEK (PDB ID: 1FVR), and
c-KIT (PDB ID: 1T45) kinases, respectively. (F) shows the
disengagement of the molecular brake at the kinase hinge region
of an “active” c-KIT kinase (PDB ID: 1PKG). Coloring scheme
is as in Figure 3.
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