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Figure 6.
Figure 6. Modeling of the Complex
(A) Structural
superposition of the four available structures of TnC complexes
(PDB codes: 1a2x, 1j1d, 1ytz, and 1yv0) with the N terminus of
TnI. The structures were superposed on the C lobe of TnC. The
comparison shows that, despite the differences in the relative
orientation of the N lobe, TnI interacts in the same groove and
adopts the same relative orientation to the C lobe.
(B)
Comparison of the network of interactions formed between the C
lobe of TnC and TnI in the cardiac complex (Takeda et al., 2003)
(left panel) and in a homology model built (right panel) using
the cardiac structure (PDB code: 1j1d) as a template. The side
chains of the key residues involved are displayed explicitly and
labeled in red and green according to whether they correspond to
TnI and TnC, respectively, for the cardiac structure. Similarly,
they are colored in red and blue according to whether they
correspond to Lethocerus TnH and TnC, respectively.
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