|
Figure 6.
Figure 6. A comparison of the Pygo1 PHD domain with the ING2
and BPTF PHD domains. (a) A superposition of the Pygo1 PHD
domain (pink) onto the ING2 (green) and BPTF (cyan) PHD domains
complexed with the H3K4me3 histone peptides. The H3K4me3
peptides are shown by stick models and the trimethylated lysines
are labeled. (b) A representative electrostatic surface
potential of the ING2 complex. The H3K4me3 peptide is shown by a
stick model. (c) An electrostatic surface potential of the
Pygo1 PHD domain (chain A only) near the H3K4me3 binding
region. Panels (b) and (c) are in the same orientation as in
(a). The surfaces are colored blue and red for positive and
negative electrostatic surface potential, respectively.
Figure 6. A comparison of the Pygo1 PHD domain with the ING2 and
BPTF PHD domains. (a) A superposition of the Pygo1 PHD domain
(pink) onto the ING2 (green) and BPTF (cyan) PHD domains
complexed with the H3K4me3 histone peptides. The H3K4me3
peptides are shown by stick models and the trimethylated lysines
are labeled. (b) A representative electrostatic surface
potential of the ING2 complex. The H3K4me3 peptide is shown by a
stick model. (c) An electrostatic surface potential of the Pygo1
PHD domain (chain A only) near the H3K4me3 binding region.
Panels (b) and (c) are in the same orientation as in (a). The
surfaces are colored blue and red for positive and negative
electrostatic surface potential, respectively.
|
