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Figure 6.
Figure 6: A model of auxin-regulated TIR1–substrate
interactions. A schematic diagram of auxin functioning
as a 'molecular glue' to enhance TIR1–substrate interactions.
In contrast to an allosteric mechanism, auxin binds to the same
TIR1 pocket that docks the Aux/IAA substrate. Without inducing
significant conformational changes in its receptor, auxin
increases the affinity of two proteins by simultaneously
interacting with both in a cavity at the protein interface.
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