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Figure 6.
The canyon-like deep active-site cleft.A, a side view of the
active site from the right of the molecule in Fig. 2A. The
coloring scheme is as in Fig. 2A. The ionic interaction between
Arg-160 and Glu-263 is shown as a dotted line. B, surface
representation of PPAF-I is shown with a Cα worm. The region
and orientation of the molecule are similar to those in Fig. 4A.
The surface representation was generated from a virtual mutant
molecule (R160A/E263A), and it was perpendicularly clipped just
before the catalytic serine residue for clarity. The distance
between Arg-160 and the O-γ of Ser-315 is 11.1 Å as shown.
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